By Tim D. Spector, Harold Snieder, Alex J. MacGregor
Dual and relatives information have normally been used to quantify the genetic and environmental contribution to ailment. throughout the software of latest analytical techniques, those designs may also offer robust versions within which the quest for particular genes underlying non-Mendelian ailments will be optimised. This e-book discusses the state of the art in dual and sib-pairs research of complicated ailments either from the viewpoint of epidemiology (study layout, topic choice, sampling thoughts) and biostatistics (path research, survival research, linkage research, organization studies). Novel methods are mentioned within which twins and sib-pairs can be utilized to satisfy the problem of picking out the positioning and serve as of genes underlying complicated qualities. This ebook will entice a variety of biomedical scientists attracted to the genetic foundation of illness, epidemiologists, molecular biologists, human geneticists and scholars.
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Extra info for Advances in Twin and Sib-pair Analysis
London 17 Morgan TH. Random segregation versus coupling in Mendelian Inheritance. Science 1911;34: 384 18 Engledow FL, Yule GU. The determination of the best value of the coupling ratio from a given set of data. Proc Camb Phil. Soc. 1914;17: 436-440. 19 Haldane JBS. The combination of linkage values, and the calculation of distances between the loci of linked factors. Journal of Genetics 1919;8: 299-309 20 Penrose LS. The detection of autosomal linkage in data which consist of pairs of brothers and sisters of unspecified parentage.
Conclusions Many theoretical considerations suggest that the design of twin studies should influence the outcome, particularly the measurement of concordance rates and the estimation of heritability. However, there are remarkably few examples in the published literature where these predictions have been tested. More comparisons of this type are needed if the results from less comprehensive methods of twin identification or disease ascertainment are to be interpreted with greater confidence. However, few twin studies are entirely free from bias and the consequences of each design should be considered for each study in its own context.
Data on 11, 154 adult Finnish twin pairs from a nationwide panel. Acta Geneticae Medicae et Gemellologiae 1990;39: 441-446. 30 Kendler KS, Pedersen N, Johnson L, Neale MC, Mathe AA. A pilot Swedish twin study of affective illness, including hospital- and population-ascertained subsamples. Archives of General Psychiatry 1993;50: 699-700. 31 Walker E, Downey G, Caspi A. Twin studies of psychopathology: why do the concordance rates vary? Schizophrenia Research 1991;5: 211-221. Page 23 3 Sample Selection and Outcome Definition in Twin Studies: Experiences From the Finnish Twin Cohort Study Jaakko Kaprio Pia K.